Irinotecan pharmacogenomics
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity.
The human UDP-glucuronosyltransferases (UGTs) represent a superfamily of proteins (Mackenzie et al., 1997) that are attracting much interest because of their extensive polymorphic patterns of gene and tissue specific expression (Mackenzie et al., 2000; Tukey and Strassburg, 2000). Because glucuronidation comprises a significant pathway for drug detoxification and elimination, polymorphic patter...
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Background: FOLFIRI regimen, which is composed of 5-FU, Leucovorin, and Irinotecan, is used in the first-line chemotherapy of metastatic colorectal cancer. Irinotecan life threatening toxicity is partly related to cytotoxic drug metabolite which is primarily inactivated by the UGT1A1 enzyme. The primary aim of the present research was to find the correlation between UGT1A1-genotype and clinical...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2010
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.10.95